The NLRP4 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NLRP4. This antibody recognizes Human, Mouse, and Rat antigen. The NLRP4 Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Immunohistochemistry.
Description
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e. g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes